Understanding the Dynamic Regulation of Exhausted and Tissue-Resident Memory T Cells Differentiation in Tumors
Grant number: 1185346 | Funding period: 2020 - 2022
Completed
Abstract
Despite recent breakthroughs in immunotherapy, cancer remains a major threat to health. T cells play a major role in tumor control and their killer function is central to immunotherapy. However, it is poorly understood which types of T cells contribute to anti-tumor immunity and which mechanisms limit their function. Using a new preclinical model, we will track the development, function and fate of distinct intratumoral T cell subtypes and examine how we can control their anti-tumor activity.